Design of an engineered N-terminal HIV-1 gp41 trimer with enhanced stability and potency

HIV fusion is mediated by a conformational transition in which the C-terminal region (HR2) of gp41 interacts with the N-terminal region (HR1) to form a six-helix bundle. Peptides derived from the HR1 form a well-characterized, trimeric coiled-coil bundle in the presence of HR2 peptides, but there is...

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Main Authors: Dwyer, John J., Wilson, Karen L., Martin, Kimberly, Seedorff, Jennifer E., Hasan, Aisha, Medinas, Robyn J., Davison, Donna K., Feese, Michael D., Richter, Hans-Thomas, Kim, Hidong, Matthews, Thomas J., Delmedico, Mary K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271165/
https://ncbi.nlm.nih.gov/pubmed/18359857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073307608
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