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Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding
The aggregation of antitrypsin into polymers is one of the causes of neonatal hepatitis, cirrhosis, and emphysema. A similar reaction resulting in disease can occur in other human serpins, and collectively they are known as the serpinopathies. One possible therapeutic strategy involves inhibiting th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2590919/ https://ncbi.nlm.nih.gov/pubmed/18780818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.037234.108 |
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