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New roles for pyruvate kinase M2: working out the Warburg effect
The origins and role of the Warburg effect have remained uncertain for many years. Two recent studies demonstrate that an embryonic- and cancer-cell-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is regulated by binding to phospho-tyrosine motifs and promotes increased cell growth and tumo...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2590867/ https://ncbi.nlm.nih.gov/pubmed/18603432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2008.05.006 |
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