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G(0) Function of BCL2 and BCL-x(L) Requires BAX, BAK, and p27 Phosphorylation by Mirk, Revealing a Novel Role of BAX and BAK in Quiescence Regulation

BCL2 and BCL-x(L) facilitate G(0) quiescence by decreasing RNA content and cell size and up-regulating p27 protein, but the precise mechanism is not understood. We investigated the relationship between cell cycle regulation and the anti-apoptosis function of BCL2 and BCL-x(L). Neither caspase inhibi...

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Detalhes bibliográficos
Main Authors: Janumyan, Yelena, Cui, Qinghua, Yan, Ling, Sansam, Courtney G., Valentin, Mayda, Yang, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590681/
https://ncbi.nlm.nih.gov/pubmed/18818203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806294200
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