Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene

BACKGROUND: Methylation-sensitive high resolution melting (MS-HRM) methodology is able to recognise heterogeneously methylated sequences by their characteristic melting profiles. To further analyse heterogeneously methylated sequences, we adopted a digital approach to MS-HRM (dMS-HRM) that involves...

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Main Authors: Candiloro, Ida LM, Mikeska, Thomas, Hokland, Peter, Dobrovic, Alexander
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Methodology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590600/
https://ncbi.nlm.nih.gov/pubmed/19014416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-1-7
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