IRF7 activation by Epstein–Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3

Epstein–Barr virus (EBV) latent infection membrane protein 1 (LMP1), a constitutively aggregated and activated pseudoreceptor, activates IFN regulatory factor 7 (IRF7) through RIP1. We now report that the LMP1 cytoplasmic carboxyl terminal amino acids 379–386 bound IRF7 and activated IRF7. IRF7 acti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Song, Yoon-Jae, Izumi, Kenneth M., Shinners, Nicholas P., Gewurz, Benjamin E., Kieff, Elliott
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587557/
https://ncbi.nlm.nih.gov/pubmed/19017798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809933105
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