Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin

The Gram-negative bacterium Vibrio cholerae is the causative agent of a severe diarrheal disease that afflicts three to five million persons annually, causing up to 200,000 deaths. Nearly all V. cholerae strains produce a large multifunctional-autoprocessing RTX toxin (MARTX(Vc)), which contributes...

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Hauptverfasser: Kudryashov, Dmitri S., Durer, Zeynep A. Oztug, Ytterberg, A. Jimmy, Sawaya, Michael R., Pashkov, Inna, Prochazkova, Katerina, Yeates, Todd O., Loo, Rachel R. Ogorzalek, Loo, Joseph A., Satchell, Karla J. Fullner, Reisler, Emil
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587553/
https://ncbi.nlm.nih.gov/pubmed/19015515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808082105
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