Synthesis, Ex Vivo Evaluation and Radiolabeling of Potent 1,5-Diphenyl-pyrrolidin-2-one Cannabinoid Subtype-1 (CB(1)) Receptor Ligands as Candidates for In Vivo Imaging

We have reported that [methyl-(11)C](3R,5R)-5-(3-methoxy-phenyl)-3-((R)-1-phenyl-ethylamino)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one ([(11)C]8, [(11)C]MePPEP) binds with high selectivity to cannabinoid type-1 (CB(1)) receptors in monkey brain in vivo. We now describe the synthesis of 8 and fou...

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Auteurs principaux: Donohue, Sean R., Krushinski, Joseph H., Pike, Victor W., Chernet, Eyassu, Lee, Phebus, Chesterfield, Amy K., Felder, Christian C., Halldin, Christer, Schaus, John M.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587418/
https://ncbi.nlm.nih.gov/pubmed/18800770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800416m
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