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Cutting Edge: Inflammasome activation by Alum and Alum’s adjuvant effect are mediated by NLRP3

Alum is the only adjuvant approved for routine use in humans, although the basis for its adjuvanticity remains poorly understood. We have recently shown that Alum activates caspase-1 and induces secretion of mature IL-1β and IL-18. Here we show that in human and mice macrophages, alum-induced IL-1β,...

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Bibliografiske detaljer
Main Authors: Li, Hanfen, Willingham, Stephen B., Ting, Jenny P-Y., Re, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587213/
https://ncbi.nlm.nih.gov/pubmed/18566365
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