CARP-2 is an endosome-associated ubiquitin protein ligase for RIP and regulates TNF-induced NF-κB activation

BACKGROUND: The proinflammatory cytokine Tumor Necrosis Factor–α (TNF) elicits cellular responses by signaling through a receptor complex that includes the essential adaptor molecule RIP. One important consequence of signaling is activation of the transcription factor NF-κB, and failure to downregul...

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Main Authors: Liao, Wentao, Xiao, Qi, Tchikov, Vladimir, Fujita, Ken-ichi, Yang, Wensheng, Wincovitch, Stephen, Garfield, Susan, Conze, Dietrich, El-Deiry, Wafik S., Schutze, Stefan, Srinivasula, Srinivasa M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587165/
https://ncbi.nlm.nih.gov/pubmed/18450452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2008.04.017
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