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Total Synthesis of (–)- and ent-(+)-Vindoline

Two exceptionally concise total syntheses of (–)- and ent-(+)-vindoline are detailed enlisting a diastereoselective tandem [4+2]/[3+2] cycloaddition of a 1,3,4-oxadiazole. The unique reaction cascade assembles the fully functionalized pentacyclic ring system of vindoline in a single step that forms...

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Main Authors: Choi, Younggi, Ishikawa, Hayato, Velcicky, Juraj, Elliott, Gregory I., Miller, Michael M., Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587129/
https://ncbi.nlm.nih.gov/pubmed/16178578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol051975x
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