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Total Synthesis of (−)- and ent-(+)-Vindoline and Related Alkaloids

A concise 11-step total synthesis of (−)- and ent-(+)-vindoline (3) is detailed based on a unique tandem intramolecular [4+2]/[3+2] cycloaddition cascade of a 1,3,4-oxadiazole inspired by the natural product structure, in which three rings and four C–C bonds are formed central to the characteristic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ishikawa, Hayato, Elliott, Gregory I., Velcicky, Juraj, Choi, Younggi, Boger, Dale L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531198/
https://ncbi.nlm.nih.gov/pubmed/16895428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja061256t
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