Smokers with the CHRNA Lung Cancer-Associated Variants are Exposed to Higher Levels of Nicotine Equivalents and a Carcinogenic Tobacco-Specific Nitrosamine

A locus at 15q24/15q25.1, which includes the nicotinic acetylcholine receptor A subunits 3 and 5 (CHRNA3, CHRNA5) genes, has recently been associated with lung cancer risk, self-reported number of cigarettes smoked per day and a nicotine-dependence scale. It is not clear whether the association with...

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Detalhes bibliográficos
Main Authors: Marchand, Loïc Le, Derby, Kiersten S., Murphy, Sharon E., Hecht, Stephen S., Hatsukami, Dorothy, Carmella, Steven G., Tiirikainen, Maarit, Wang, Hansong
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587068/
https://ncbi.nlm.nih.gov/pubmed/19010884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2271
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