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PI3K Hyperactivation Results in Lapatinib Resistance that is Reversed by the mTOR/PI3K Inhibitor NVP-BEZ235

Small molecule inhibitors of HER2 are clinically active in women with advanced HER2 positive breast cancer who have progressed on trastuzumab treatment. However, the effectiveness of this class of agents is limited by either primary resistance or acquired resistance. Using an unbiased genetic approa...

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Détails bibliographiques
Auteurs principaux: Eichhorn, Pieter J.A., Gili, Magüi, Scaltriti, Maurizio, Serra, Violeta, Guzman, Marta, Nijkamp, Wouter, Beijersbergen, Roderick L., Valero, Vanesa, Seoane, Joan, Bernards, René, Baselga, José
Format: Artigo
Langue:Inglês
Publié: 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587064/
https://ncbi.nlm.nih.gov/pubmed/19010894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1740
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