PI3K Hyperactivation Results in Lapatinib Resistance that is Reversed by the mTOR/PI3K Inhibitor NVP-BEZ235

Small molecule inhibitors of HER2 are clinically active in women with advanced HER2 positive breast cancer who have progressed on trastuzumab treatment. However, the effectiveness of this class of agents is limited by either primary resistance or acquired resistance. Using an unbiased genetic approa...

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Bibliografiske detaljer
Main Authors: Eichhorn, Pieter J.A., Gili, Magüi, Scaltriti, Maurizio, Serra, Violeta, Guzman, Marta, Nijkamp, Wouter, Beijersbergen, Roderick L., Valero, Vanesa, Seoane, Joan, Bernards, René, Baselga, José
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587064/
https://ncbi.nlm.nih.gov/pubmed/19010894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1740
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