Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

We have generated lines of transgenic mice that express a mutant prion protein (PrP) containing 14 octapeptide repeats whose human homologue is associated with an inherited prion dementia. These mice develop a neurological illness with prominent ataxia at 65 or 240 days of age, depending on whether...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Chiesa, Roberto, Drisaldi, Bettina, Quaglio, Elena, Migheli, Antonio, Piccardo, Pedro, Ghetti, Bernardino, Harris, David A.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 2000
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25870/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805813/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5574
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