Absence of COX-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells

BACKGROUND: Cyclooxygenase-2 (COX-2) is upregulated in pulmonary artery smooth muscle cells (PASMC) during hypoxia and may play a protective role in the lung’s response to hypoxia. Selective COX-2 inhibition may have detrimental pulmonary vascular consequences during hypoxia. METHODS AND RESULTS: To...

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Autores principales: Fredenburgh, Laura E., Liang, Olin D., Macias, Alvaro A., Polte, Thomas R., Liu, Xiaoli, Riascos, Dario F., Chung, Su Wol, Schissel, Scott L., Ingber, Donald E., Mitsialis, S. Alex, Kourembanas, Stella, Perrella, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586933/
https://ncbi.nlm.nih.gov/pubmed/18391113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.716241
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