Divergent Cardiopulmonary Actions of Heme Oxygenase Enzymatic Products in Chronic Hypoxia

BACKGROUND: Hypoxia and pressure-overload induce heme oxygenase-1 (HO-1) in cardiomyocytes and vascular smooth muscle cells (VSMCs). HO-1(−/−) mice exposed to chronic hypoxia develop pulmonary arterial hypertension (PAH) with exaggerated right ventricular (RV) injury consisting of dilation, fibrosis...

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Hauptverfasser: Vitali, Sally H., Mitsialis, S. Alex, Liang, Olin D., Liu, Xiaoli, Fernandez-Gonzalez, Angeles, Christou, Helen, Wu, Xinqi, McGowan, Francis X., Kourembanas, Stella
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694354/
https://ncbi.nlm.nih.gov/pubmed/19543386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005978
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