Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice

Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO) and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and smooth muscle development. Bilirubin is a potent antioxidant. Hypoxia increases expression of the inducible HO isoform (HO-1) bu...

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Main Authors: Yet, Shaw-Fang, Perrella, Mark A., Layne, Matthew D., Hsieh, Chung-Ming, Maemura, Koji, Kobzik, Lester, Wiesel, Philippe, Christou, Helen, Kourembanas, Stella, Lee, Mu-En
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC408281/
https://ncbi.nlm.nih.gov/pubmed/10207174
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