Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice

Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO) and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and smooth muscle development. Bilirubin is a potent antioxidant. Hypoxia increases expression of the inducible HO isoform (HO-1) bu...

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Main Authors: Yet, Shaw-Fang, Perrella, Mark A., Layne, Matthew D., Hsieh, Chung-Ming, Maemura, Koji, Kobzik, Lester, Wiesel, Philippe, Christou, Helen, Kourembanas, Stella, Lee, Mu-En
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1999
Assuntos:
Rapid Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC408281/
https://ncbi.nlm.nih.gov/pubmed/10207174
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