Absence of COX-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells

BACKGROUND: Cyclooxygenase-2 (COX-2) is upregulated in pulmonary artery smooth muscle cells (PASMC) during hypoxia and may play a protective role in the lung’s response to hypoxia. Selective COX-2 inhibition may have detrimental pulmonary vascular consequences during hypoxia. METHODS AND RESULTS: To...

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Main Authors: Fredenburgh, Laura E., Liang, Olin D., Macias, Alvaro A., Polte, Thomas R., Liu, Xiaoli, Riascos, Dario F., Chung, Su Wol, Schissel, Scott L., Ingber, Donald E., Mitsialis, S. Alex, Kourembanas, Stella, Perrella, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586933/
https://ncbi.nlm.nih.gov/pubmed/18391113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.716241
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