Absence of COX-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells

BACKGROUND: Cyclooxygenase-2 (COX-2) is upregulated in pulmonary artery smooth muscle cells (PASMC) during hypoxia and may play a protective role in the lung’s response to hypoxia. Selective COX-2 inhibition may have detrimental pulmonary vascular consequences during hypoxia. METHODS AND RESULTS: To...

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Bibliografische gegevens
Hoofdauteurs: Fredenburgh, Laura E., Liang, Olin D., Macias, Alvaro A., Polte, Thomas R., Liu, Xiaoli, Riascos, Dario F., Chung, Su Wol, Schissel, Scott L., Ingber, Donald E., Mitsialis, S. Alex, Kourembanas, Stella, Perrella, Mark A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586933/
https://ncbi.nlm.nih.gov/pubmed/18391113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.716241
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