NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation

Expression of nucleotide-binding oligomerization domain protein 2 (NOD2) is upregulated in pulmonary artery smooth muscle cells (PASMCs) during hypoxia. To investigate the involvement of NOD2 in the pulmonary vascular response to hypoxia, we subjected wild-type and NOD2-deficient mice to chronic nor...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kwon, Min-Young, Hwang, Narae, Park, Young-Jun, Perrella, Mark A., Chung, Su Wol
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849164/
https://ncbi.nlm.nih.gov/pubmed/29560100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23912
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