Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA damage response, an inducible process required for the suppression of malignancy. The Mre11 complex is predominantly required for repair and checkpoint activation in S phase, while Chk2 governs apoptosis. We examined...

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Bibliographic Details
Main Authors: Stracker, Travis H., Couto, Suzana S., Cordon-Cardo, Carlos, Matos, Tulio, Petrini, John H. J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586815/
https://ncbi.nlm.nih.gov/pubmed/18614044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.04.028
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