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Allergen Uptake, Activation, and IL-23 Production by Pulmonary Myeloid DCs Drives Airway Hyperresponsiveness in Asthma-Susceptible Mice

Maladaptive, Th2-polarized inflammatory responses are integral to the pathogenesis of allergic asthma. As regulators of T cell activation, dendritic cells (DCs) are important mediators of allergic asthma, yet the precise signals which render endogenous DCs “pro-asthmatic”, and the extent to which th...

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Main Authors: Lewkowich, Ian P., Lajoie, Stephane, Clark, Jennifer R., Herman, Nancy S., Sproles, Alyssa A., Wills-Karp, Marsha
格式: Artigo
語言:Inglês
出版: Public Library of Science 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586658/
https://ncbi.nlm.nih.gov/pubmed/19060952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003879
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