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Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation

Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity receptor for IgE (FcεRI) leads to degranulation and allergic inflammation; however, the regulatory mechanisms of IgE-dependent exocytosis remain unknown. We show here that IκB kinase (IKK) 2 in mast...

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Detalhes bibliográficos
Main Authors: Suzuki, Kotaro, Verma, Inder M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586340/
https://ncbi.nlm.nih.gov/pubmed/18692471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.05.050
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