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Interaction of Herpes Primase with the Sugar of a NTP

We analyzed the interaction of NTPs containing modified sugars to develop a better understanding of how DNA primase from herpes simplex virus I catalyzes primer synthesis. During the NTP binding reaction, primase tolerated a large number of modifications to the sugar ring. Altering the 2′ and 3′ car...

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Detalhes bibliográficos
Main Authors: Keller, Kristopher E., Cavanaugh, Nisha, Kuchta, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586337/
https://ncbi.nlm.nih.gov/pubmed/18672908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8008467
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