Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID Repopulating cells

OBJECTIVES: Human cord blood (CB) is a potential source of hematopoietic stem cells (HSC) for gene therapy to treat patients with hematopoietic disorders. However, limited numbers of CB CD34(+) cells, low transduction efficiency with lentiviral vectors (LVs), and low engraftment efficiency of NOD/SC...

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Hauptverfasser: Liu, Ying, Hangoc, Giao, Campbell, Timothy B., Goodman, Michael, Tao, Wen, Pollok, Karen, Srour, Edward F., Broxmeyer, Hal E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586287/
https://ncbi.nlm.nih.gov/pubmed/18640494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.06.005
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