Transduction of Human CD34(+) Repopulating Cells with a Self-Inactivating Lentiviral Vector for SCID-X1 Produced at Clinical Scale by a Stable Cell Line

Self-inactivating (SIN)-lentiviral vectors have safety and efficacy features that are well suited for transduction of hematopoietic stem cells (HSCs), but generation of vector at clinical scale has been challenging. Approximately 280 liters of an X-Linked Severe Combined Immunodeficiency Disorder (S...

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Detalhes bibliográficos
Main Authors: Greene, Michael R., Lockey, Timothy, Mehta, Perdeep K., Kim, Yoon-Sang, Eldridge, Paul W., Gray, John T., Sorrentino, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732136/
https://ncbi.nlm.nih.gov/pubmed/23075105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.150
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