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Cysteine-iron promotes arginase activity by driving the Fenton reaction

Impairment of nitric oxide bioavailability secondary to increased arginase activity and overproduction of reactive oxygen species (ROS) is thought to be a major cause of vascular complications in sickle cell disease (SCD). However, the role of ROS in the induction of arginase activity is unknown. Th...

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Autors principals: Iyamu, Efemwonkiekie W., Perdew, Harrison, Woods, Gerald M.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585818/
https://ncbi.nlm.nih.gov/pubmed/18762165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.08.102
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