High Levels of Intracellular Cysteine Promote Oxidative DNA Damage by Driving the Fenton Reaction

Escherichia coli is generally resistant to H(2)O(2), with >75% of cells surviving a 3-min challenge with 2.5 mM H(2)O(2). However, when cells were cultured with poor sulfur sources and then exposed to cystine, they transiently exhibited a greatly increased susceptibility to H(2)O(2), with <1%...

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Bibliografiske detaljer
Main Authors: Park, Sunny, Imlay, James A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Physiology and Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150142/
https://ncbi.nlm.nih.gov/pubmed/12618458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.6.1942-1950.2003
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