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Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin

PURPOSE: Heterozygous mutations in the myocilin gene (MYOC) cause glaucoma by an unknown mechanism. MYOC encodes an extracellular protein of unidentified function that undergoes intracellular endoproteolytic processing in the secretory pathway. It has been described that co-expression of wild-type/m...

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Main Authors: Aroca-Aguilar, José-Daniel, Sánchez-Sánchez, Francisco, Martínez-Redondo, Francisco, Coca-Prados, Miguel, Escribano, Julio
Formáid: Artigo
Teanga:Inglês
Foilsithe: Molecular Vision 2008
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585175/
https://ncbi.nlm.nih.gov/pubmed/19023451
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