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Experimental identification of specificity determinants in the domain linker of a LacI/GalR protein: Bioinformatics-based predictions generate true positives and false negatives

In protein families, conserved residues often contribute to a common general function, such as DNA-binding. However, unique attributes for each homologue (e.g. recognition of alternative DNA sequences) must arise from variation in other functionally-important positions. The locations of these “speci...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Meinhardt, Sarah, Swint-Kruse, Liskin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585155/
https://ncbi.nlm.nih.gov/pubmed/18536016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22121
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