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Experimental identification of specificity determinants in the domain linker of a LacI/GalR protein: Bioinformatics-based predictions generate true positives and false negatives
In protein families, conserved residues often contribute to a common general function, such as DNA-binding. However, unique attributes for each homologue (e.g. recognition of alternative DNA sequences) must arise from variation in other functionally-important positions. The locations of these “speci...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585155/ https://ncbi.nlm.nih.gov/pubmed/18536016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22121 |
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