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Probing Gorge Dimensions of Cholinesterases by Freeze-Frame Click Chemistry
Freeze-frame click chemistry is a proven approach for design in situ of high affinity ligands from bioorthogonal, reactive building blocks and macromolecular template targets. We recently described in situ design of femtomolar reversible inhibitors of fish and mammalian acetylcholinesterases (EC 3.1...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585062/ https://ncbi.nlm.nih.gov/pubmed/18555981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2008.04.048 |
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