Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells

Elevated levels of serum uric acid (UA) are commonly associated with primary pulmonary hypertension but have generally not been thought to have any causal role. Recent experimental studies, however, have suggested that UA may affect various vasoactive mediators. We therefore tested the hypothesis th...

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Hlavní autoři: Zharikov, Sergey, Krotova, Karina, Hu, Hanbo, Baylis, Chris, Johnson, Richard J., Block, Edward R., Patel, Jawaharlal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
Témata:
Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584985/
https://ncbi.nlm.nih.gov/pubmed/18784379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00075.2008
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