Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells

Elevated levels of serum uric acid (UA) are commonly associated with primary pulmonary hypertension but have generally not been thought to have any causal role. Recent experimental studies, however, have suggested that UA may affect various vasoactive mediators. We therefore tested the hypothesis th...

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Detalhes bibliográficos
Main Authors: Zharikov, Sergey, Krotova, Karina, Hu, Hanbo, Baylis, Chris, Johnson, Richard J., Block, Edward R., Patel, Jawaharlal
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584985/
https://ncbi.nlm.nih.gov/pubmed/18784379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00075.2008
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