Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA

The cAMP-PKA cascade is a recognized signaling pathway important in inhibition of inflammatory injury events such as endothelial permeability and leucocyte trafficking, and a critical target of regulation is believed to be inhibition of Rho proteins. Here, we hypothesize that PKA directly phosphoryl...

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Hlavní autoři: Qiao, Jing, Holian, Oksana, Lee, Bao-Shiang, Huang, Fei, Zhang, Jihang, Lum, Hazel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
Témata:
Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584978/
https://ncbi.nlm.nih.gov/pubmed/18768928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00139.2008
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