Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects

BACKGROUND AND PURPOSE: Several P2X(7) receptor antagonists are allosteric inhibitors and exhibit species difference in potency. Furthermore, N(2)-(3,4-difluorophenyl)-N(1)-(2-methyl-5-(1-piperazinylmethyl)phenyl)glycinamide dihydrochloride (GW791343) exhibits negative allosteric effects at the huma...

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Main Authors: Michel, A D, Clay, W C, Ng, S W, Roman, S, Thompson, K, Condreay, J P, Hall, M, Holbrook, J, Livermore, D, Senger, S
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584934/
https://ncbi.nlm.nih.gov/pubmed/18660826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.306
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