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Direct labelling of the human P2X(7) receptor and identification of positive and negative cooperativity of binding
BACKGROUND AND PURPOSE: The P2X(7) receptor exhibits complex pharmacological properties. In this study, binding of a [(3)H]-labelled P2X(7) receptor antagonist to human P2X(7) receptors has been examined to further understand ligand interactions with this receptor. EXPERIMENTAL APPROACH: The P2X(7)...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2012979/ https://ncbi.nlm.nih.gov/pubmed/17339830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707196 |
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