Direct labelling of the human P2X(7) receptor and identification of positive and negative cooperativity of binding

BACKGROUND AND PURPOSE: The P2X(7) receptor exhibits complex pharmacological properties. In this study, binding of a [(3)H]-labelled P2X(7) receptor antagonist to human P2X(7) receptors has been examined to further understand ligand interactions with this receptor. EXPERIMENTAL APPROACH: The P2X(7)...

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Main Authors: Michel, A D, Chambers, L J, Clay, W C, Condreay, J P, Walter, D S, Chessell, I P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2012979/
https://ncbi.nlm.nih.gov/pubmed/17339830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707196
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