Mechanism of action of species-selective P2X(7) receptor antagonists

BACKGROUND AND PURPOSE: AZ11645373 and N-{2-methyl-5-[(1R, 5S)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-ylcarbonyl]phenyl}-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide hydrochloride (compound-22) are recently described P2X(7) receptor antagonists. In this study we have further characterized these compounds to...

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Detalhes bibliográficos
Main Authors: Michel, Anton D, Ng, Sin-Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697735/
https://ncbi.nlm.nih.gov/pubmed/19309360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00135.x
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