MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation

UT-A1 is the primary urea transporter in the apical plasma membrane responsible for urea reabsorption in the inner medullary collecting duct. Although the physiological function of UT-A1 has been well established, the molecular mechanisms that regulate its activity are less well understood. Analysis...

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Detalhes bibliográficos
Main Authors: Chen, Guangping, Huang, Haidong, Fröhlich, Otto, Yang, Yuan, Klein, Janet D., Price, S. Russ, Sands, Jeff M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584914/
https://ncbi.nlm.nih.gov/pubmed/18784257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90482.2008
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