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Mice expressing BMPR2(R899X) transgene in smooth muscle develop pulmonary vascular lesions
Familial pulmonary arterial hypertension (PAH) is associated with mutations in bone morphogenetic protein type II receptor (BMPR2). Many of these mutations occur in the BMPR2 tail domain, leaving the SMAD functions intact. To determine the in vivo consequences of BMPR2 tail domain mutation, we creat...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584890/ https://ncbi.nlm.nih.gov/pubmed/18723761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90255.2008 |
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