Mice expressing BMPR2(R899X) transgene in smooth muscle develop pulmonary vascular lesions

Familial pulmonary arterial hypertension (PAH) is associated with mutations in bone morphogenetic protein type II receptor (BMPR2). Many of these mutations occur in the BMPR2 tail domain, leaving the SMAD functions intact. To determine the in vivo consequences of BMPR2 tail domain mutation, we creat...

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Bibliographische Detailangaben
Hauptverfasser: West, James, Harral, Julie, Lane, Kirk, Deng, Yupu, Ickes, Brian, Crona, Daniel, Albu, Sebastian, Stewart, Duncan, Fagan, Karen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584890/
https://ncbi.nlm.nih.gov/pubmed/18723761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90255.2008
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