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Detailed Kinetics and Regulation of Mammalian NAD-Linked Isocitrate Dehydrogenase
A mathematical model is presented to describe the catalytic mechanism of mammalian NAD-linked isocitrate dehydrogenase (NAD-IDH), a highly regulated enzyme in the tricarboxylic acid cycle, a crucial pathway in energy metabolism and biosynthesis. The mechanism accounts for allosteric regulation by ma...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584801/ https://ncbi.nlm.nih.gov/pubmed/18672100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2008.07.001 |
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