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Detailed Kinetics and Regulation of Mammalian NAD-Linked Isocitrate Dehydrogenase
A mathematical model is presented to describe the catalytic mechanism of mammalian NAD-linked isocitrate dehydrogenase (NAD-IDH), a highly regulated enzyme in the tricarboxylic acid cycle, a crucial pathway in energy metabolism and biosynthesis. The mechanism accounts for allosteric regulation by ma...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584801/ https://ncbi.nlm.nih.gov/pubmed/18672100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2008.07.001 |
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