Detailed Kinetics and Regulation of Mammalian NAD-Linked Isocitrate Dehydrogenase

A mathematical model is presented to describe the catalytic mechanism of mammalian NAD-linked isocitrate dehydrogenase (NAD-IDH), a highly regulated enzyme in the tricarboxylic acid cycle, a crucial pathway in energy metabolism and biosynthesis. The mechanism accounts for allosteric regulation by ma...

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Bibliographic Details
Main Authors: Qi, Feng, Chen, Xuewen, Beard, Daniel A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584801/
https://ncbi.nlm.nih.gov/pubmed/18672100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2008.07.001
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