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Low Concentrations of the Soy Phytoestrogen Genistein Induce Proteinase Inhibitor 9 and Block Killing of Breast Cancer Cells by Immune Cells

The risks and benefits of diets and supplements containing the estrogenic soy isoflavone genistein are not well established. We report that 10 nm genistein potently induces the granzyme B inhibitor, proteinase inhibitor 9 (PI-9) in MCF-7 human breast cancer cells. By inducing PI-9, genistein inhibit...

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Autori principali: Jiang, Xinguo, Patterson, Nicole M., Ling, Yan, Xie, Jianwei, Helferich, William G., Shapiro, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584580/
https://ncbi.nlm.nih.gov/pubmed/18669594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0857
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