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In vitro‐in silico‐based analysis of the dose‐dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans
BACKGROUND AND PURPOSE: The in vivo oestrogenicity of genistein and its glycoside genistin is still under debate. The present study aimed to develop a physiologically based kinetic (PBK) model that provides insight in dose‐dependent plasma concentrations of genistein aglycone and its metabolites and...
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| Publicat a: | Br J Pharmacol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5523000/ https://ncbi.nlm.nih.gov/pubmed/28585232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13900 |
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