Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use o...

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Veröffentlicht in:Arch Toxicol
Hauptverfasser: Strikwold, Marije, Spenkelink, Bert, de Haan, Laura H. J., Woutersen, Ruud A., Punt, Ans, Rietjens, Ivonne M. C. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
Schlagworte:
Toxicokinetics and Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399052/
https://ncbi.nlm.nih.gov/pubmed/27815601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1881-x
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