Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin

Disease-related PrP(Sc) [pathogenic PrP (prion protein)] is classically distinguished from its normal cellular precursor, PrP(C)(cellular PrP) by its detergent insolubility and partial resistance to proteolysis. Although molecular diagnosis of prion disease has historically relied upon detection of...

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Hlavní autoři: Cronier, Sabrina, Gros, Nathalie, Tattum, M. Howard, Jackson, Graham S., Clarke, Anthony R., Collinge, John, Wadsworth, Jonathan D. F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584334/
https://ncbi.nlm.nih.gov/pubmed/18684106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081235
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