Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human β-globin in engrafted mice

Transcriptional silencing of genes transferred into hematopoietic stem cells poses one of the most significant challenges to the success of gene therapy. If the transferred gene is not completely silenced, a progressive decline in gene expression as the mice age often is encountered. These phenomena...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kalberer, Christian P., Pawliuk, Robert, Imren, Suzan, Bachelot, Thomas, Takekoshi, Ken J., Fabry, Mary, Eaves, Connie J., London, Irving M., Humphries, R. Keith, Leboulch, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC25842/
https://ncbi.nlm.nih.gov/pubmed/10792053
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados